郭玉潔
博士，助理研究員(yuán)
Email:guoyujie@@gdiist.cn
個人簡介：
中(zhōng)國科學技術大(dà)學合肥微尺度物(wù)質科學國家研究中(zhōng)心神經生(shēng)物(wù)學博士，四川大(dà)學華西醫院生(shēng)物(wù)治療國家重點實驗室基礎醫學博士後。2022年8月加入江門市新會區威信高技術科學研究所，主要關注神經和精神疾病環路機制。既往研究包括：建立了一(yī)種新型的自殘動物(wù)模型，在此基礎上發現了多個與動物(wù)自殘相關的腦區，繪制了第一(yī)張自殘相關腦區圖譜，解開(kāi)了一(yī)條情緒影響自殘行爲的通路。以第一(yī)（含共同）作者身份發表學術論文多篇。主持國家自然科學基金青年科學基金、中(zhōng)國博士後科學基金面上資(zī)助（一(yī)等）、四川省科技廳重點研發項目等國家和省部級科研項目多項。
研究方向：
[1]自殘行爲/抑郁症的神經環路機制
[2]α-突觸核蛋白(bái)腦内傳播擴散的神經環路機制
代表論著：
[1] Guo Y, Tang X, Zhang J, Jin S, Li J, Ding L, Zhang K, Yang C, Zhou H, He X, Xu F, Bi G-Q, Xu L & Lau P-M. Corticosterone signaling and a lateral habenula-ventral tegmental area circuit modulate compulsive self-injurious behavior in a rat model. Journal of Neuroscience, 2018, 38(23): 5251-5266. (reported by AAAS)
[2] Guo Y, Xiong H, Chen K, Zou J, Lei P, Brain regions susceptible to alpha-synuclein spreading. Molecular Psychiatry, 2022, 27(1): 758-770.
[3] Guo Y, Ayton S, Lei P. Iron reduces the propagation of pathological α-synuclein: An Editorial Highlight for "Brain iron enrichment attenuates α-synuclein spreading after injection of preformed fibrils" on page 554. Journal of Neurochemistry, 2021, 159(3): 414-416.
[4] Wang H, Zhu Q, Ding L, Shen Y, Yang C-Y, Xu F, Shu C, Guo Y, Xiong Z, Shan Q, Jia F, Su P, Yang Q-R, Li B, Cheng Y, He X, Chen X, Wu F, Zhou J-N, Xu F, Han H, Lau P-M, Bi G-Q, 2 / 3 Scalable volumetric imaging for ultrahigh-speed brain mapping at synaptic resolution. National Science Review, 2019, 6(5): 982-992.
[5] Xiong H, Tuo Q, Guo Y, Lei P, Diagnostics and treatments of iron-related CNS diseases. Advances in Experimental Medicine and Biology, 2019, 1173: 179-194.
[6] Tuo Q, Liu Y, Xiang Z, Yan H, Zou T, Shu Y, Ding X, Zou J, Xu S, Tang F, Gong Y, Li X, Guo Y, Zheng Z, Deng A, Yang Z, Li W, Zhang S, Ayton S, Bush A, Xu H, Dai L, Dong B, Lei P, Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion. Signal Transduction and Targeted Therapy, 2022, 7: 1-15.
[7] Luoqian J, Yang W, Ding X, Tuo Q, Xiang Z, Zheng Z, Guo Y, Ayton S, Dong B, Zhang H, Hu H, Lei P, Guan P, Li L, Ferroptosis promotes T cell activation-induced neurodegeneration in multiple sclerosis. Cellular & Molecular Immunology, 2022. 19(8):913-924
