王斌
博士，研究員(yuán)，研究組組長
Email：wangbin@@gdiist.cn
個人簡介：
王斌，研究員(yuán)，腦認知(zhī)神經網絡發育和疾病研究組組長。分(fēn)别于2003年7月和2006年7月在西北(běi)大(dà)學生(shēng)命科學學院獲得理學學士和碩士學位。2011年11月畢業于中(zhōng)國科學院上海生(shēng)命科學研究院，獲理學博士學位。2011年12月至2018年12月在中(zhōng)國科學院生(shēng)物(wù)化學與細胞生(shēng)物(wù)學研究所任博士後、副研究員(yuán)。2019年1月起任上海腦科學與類腦研究中(zhōng)心副研究員(yuán)。2021年9月起擔任江門市新會區威信高技術科學研究所研究員(yuán)、研究組長。曾獲得中(zhōng)國博士後面上以及特别項目、中(zhōng)科院上海生(shēng)科院博士後以及上海博士後、中(zhōng)國科學院青年創新促進會會員(yuán)以及國家自然科學基金面上項目等資(zī)助。研究成果發表于Cell Research, Cell Reports, EMBO Reports, Brain 和eLife等雜(zá)志(zhì)。
腦認知(zhī)神經網絡發育和疾病研究組：
本課題組緻力于腦認知(zhī)神經網絡發育和疾病的機理研究。通過對中(zhōng)國人群先天性智力障礙兒童進行全基因組和非編碼RNA測序分(fēn)析，建立遺傳疾病資(zī)源庫和數據庫。結合大(dà)數據分(fēn)析、人工(gōng)智能機器學習等方法對其中(zhōng)潛在的緻病基因及其變異進行篩選。進一(yī)步通過構建疾病相關的人類iPSC、類器官及人源化轉基因小(xiǎo)鼠等研究手段，探索這些基因變異對神經系統細胞功能、小(xiǎo)鼠學習、認知(zhī)和認知(zhī)相關神經網絡連接的影響，揭示其緻病性和作用機理，爲腦認知(zhī)障礙疾病的早期篩查和治療方案提供重要的理論依據。
代表論著：
(1) Wang B#,*,Jiang BW#, Li G-W#, Dong F, Luo Z, Cai B, Wei MY, Huang JS, Wang KK, Feng X, Tong F, Han QJ, Li CL, Zhang X, Yang L* and Bao L* (2022). somatosensory neurons express specific sets of lincRNAs, and lincRNA CLAP promotes itch sensation in mice. EMBO Reports, e54313. DOI: 10.15252/embr.202154313. (# Co-first authors and * Corresponding authors).
(2) Huang JS, Jiang BW, Li G-W, Zheng DD, Li MY, Xie X, Pan YX, Wei MY, Liu XY, Jiang XY, Zhang X, Yang L, Bao L*, Wang B* (2022). m6A-modified lincRNA Dubr is required for neuronal development by stabilizing YTHDF1/3 and facilitating mRNA translation. Cell Reports, 41(8):11693. (* Corresponding authors).
(3) Yin QQ, Sun LB, Cai XJ, Lou FZ, Sun Y, Wang B, Jiang BW, Bao L, Li X, Song NN, Tang SB, Bai J, Wang ZK, Wu Y, Zhou H, Wang H, Yu BW, Li QF, Wang HL (2022). Lidocaine ameliorates psoriasis by obstructing pathogenic CGRP signaling-mediated sensory neuron-derived cell communication. Journal of Investigative Dermatology, DOI: 10.1016/j.jid.2022.01.002.
(4) Wei MY, Huang JS, Li G-W, Jiang BW, Cheng H, Liu XY, Jiang XY, Zhang X, Yang L, Bao L* and Wang B* (2021). Axon-enriched lincRNA ALAE is required for axon elongation via regulating local mRNA translation. Cell Reports, 35 109053, 1-15. (* Corresponding authors).
(5) Pan XY, Zhao JR, Zhou ZY, Chen JJ, Yang ZX, Wu YX, Bai MZ, Jiao Y, Yang Y, Hu XY, Cheng TL, Lu QY, Wang B, Li CL, Lu YJ, Diao L, Zhong YQ, Pan J, Zhu JM, Xiao HS, Qiu ZL, Li JS, Wang ZF, Hui JY, Bao L, Zhang X. (2021) 5’-UTR SNP of FGF13 causes translational defect and intellectual disability. eLife, 10: e63021. DOI: https://doi.org/10.7554/eLife.63021.
(6) Jiang BW, Bao L and Wang B* (2019). Isolation of Cell-Type-Specific Neurons in Mouse Dorsal Root Ganglion by FACS. Bio-101 e1010323., 2019, Doi: 10.21769/BioProtoc.1010323. (* Corresponding author)
(7) Wang B and Bao L (2017). Axonal microRNAs: localization, function and regulatory mechanism during axon development. Journal of Molecular Cell Biology, 9: 82-90. (Cover story)
(8) Wang B #, Pan L#, Wei MY, Wang Q, Liu WW, Wang NX, Jiang XY, Zhang X and Bao L (2015). FMRP-mediated axonal delivery of miR-181d regulates axon elongation by locally targeting Map1b and Calm1. Cell Reports, 13: 2794-2807. (# Co-first authors)
(9) Chen XQ #, Wang B #, Wu C, Pan J, Yuan B, Su YY, Jiang XY, Zhang X and Bao L (2012). Endosome-mediated retrograde axonal transport of P2X3 receptor signals in primary sensory neurons. Cell Research, 22: 677-696. (# Co-first authors)
(10) Liu XJ, Zhang FX, Liu H, Li KC, Lu YJ, Wu QF, Li JY, Wang B, Wang Q, Lin LB, Zhong YQ, Xiao HS, Bao L, Zhang X (2012). Activin C expressed in nociceptive afferent neurons is required for suppressing inflammatory pain. Brain, 135: 391-403.
(11) Ma GQ, Wang B, Wang HB, Wang Q and Bao L (2008). Short elements with charged amino acids form clusters to sort protachykinin into large dense-core vesicles. Traffic, 2008; 9: 2165–2179.
